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The combination of heat, chemicals, and suction created while smoking can disturb the sensitive extraction site

Or perchance, a match or the flame of a kitchen stove

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The metabolites were assayed using a Waters HSS T3 column (1.8 m, 2.1 100 mm), where the mobile phases were A (0.1% formic acid in ddiH 2 O) and B (0.1% formic acid in acetonitrile)