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This context-sensitivity is characteristic of compounds that interact with upstream transcriptional regulators rather than directly with NOS enzymatic activity

However, when DHM was introduced, all these trends were significantly reversed

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This contrasts sharply with the DAC-modified version, which can have a half-life of 6 to 8 days due to its binding to albumin

HDL3-mediated inactivation of LDL-associated phospholipid hydroperoxides is determined by the redox status of apolipoprotein A-I and HDL particle surface lipid rigidity: relevance to inflammation and atherogenesis