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Other risk factors of cancer progression, such as the presence of lesions, are identified during the endoscopic screening or biopsy analysis

their absence induces immunosuppression, allowing subgingival pathogenic bacteria to proliferate excessively, which results in microbial dysbiosis (Niederman et al., 2001

however, their effects on the reproductive system of patients are often overlooked, especially their impact on germ cell cytogenesis, embryonic development, and reproductive system maturation