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ROS upregulate the expression of Nucleolin, n-Myc, Ddx17, and Syne2, which are most widely known for their positive participation in steps throughout ribosome biogenesis, including synthesis and processing of rRNAs, assembly of ribosomal proteins, transport to the cytoplasm and association of ribosomal subunits 29,30,43,44

Then, cells were washed three times with PBS to arrest uptake, and plasma membrane/cytosol and nuclei were labeled with CellMask Orange stain (1:20,000

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Further investigation of xanthine and glutathione's role in tamoxifen-resistant cells would highlight their prognostic value among BC patients

This can be especially helpful during weight loss, periods of high stress, or increased metabolic demand