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The RDA The recommended dietary allowance (RDA) for vitamin B 12 was last revised by the Food and Nutrition Board (FNB) of the US Institute of Medicine (now the National Academy of Medicine) in 1998 ( Table 1 )

Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)

Maximum concentrations are measured 2-4 hrs after the plasmatic peak

People with Leber hereditary optic neuropathy should not receive cyanocobalamin