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IRE1 binding with tumor necrosis factor receptor-associated factor 2 (TRAF2) activates IKK and JNK1, thus promoting chronic inflammation in IR 37,58,59 (Fig

Este mismo mecanismo que podra acelerar la reparacin de un tejido tambin podra favorecer el crecimiento de un tumor incipiente

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1 Aged Muscle Stem Cell Rejuvenation Neelakantan et al., Biochemical Pharmacology (2019) In a follow-up study, the authors tested whether NNMT inhibition could reverse the age-related decline in muscle stem cell (satellite cell) function

Proceedings of the Society for Experimental Biology and Medicine, 167(2), 283-286