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Steiger A and Holsboer F (1997)

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Then, under conditions of Cu deficiency in dopaminergic neurons, there might be an increased propensity for the formation of dopamine quinones and ROS due to autoxidation of accumulated dopamine ( Another contributor to the chronic state of oxidative stress in the body is the increase in CD8-depleted T cells (222)

116 , 117 Additionally, the BBB serves to prevent potentially harmful toxins from reaching the brain

The initial burst is likely due to presence of HSP on the outermost surface of NPs, while the sustained release indicates that the drugs release from the inner polymer phase