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Fourth, the translation of mechanistic insights from animal or in vitro models remains tentative, as these systems may not recapitulate the complex interplay of metabolic, hormonal, and immune factors in human PCOS

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Supplementation with synbiotic kefir (goat milk kefir with probiotics) in high-fat, high-fructose (HFHF) diet-fed rats lowered HbA1c levels, improved insulin production, and enhanced overall metabolic health compared with non-supplemented kefir (Nurliyani et al., 2022)

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