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From a theoretical pharmacological standpoint, combining a peptide with putative lipolytic activity (AOD 9604) with a potent triple incretin receptor agonist (retatrutide) could potentially amplify metabolic effects but this is speculative and raises the possibility of compounding adverse effects with no safety data to guide dosing or monitoring

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Approach Short trial arm Duration 12 weeks Review Point Week 12 Notes METAOD005 used 12 weeks at oral doses 1-30 mg/day in 300 obese adults

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