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For people who are younger than the legal drinking age of 21, or for pregnant women, any alcohol use is considered alcohol misuse

Researchers associate nicotine with sleep disruption increased risk of cardiovascular disease obesity poorer cognitive performance mental and emotional impairment This article looks at how nicotine affects sleep quality, how long nicotine can keep a person awake, and factors that can influence how long nicotine remains in the body

The nicotine can irritate the mucus membrane lining the throat and esophagus, potentially causing hiccups

Health.unl.edu

For example, there is substantial evidence showing that propylene glycol, vitamin E acetate, and metals such as lead and arsenic are important components of some e-cigarettes [22,23,24]