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Notably, the NF-B inhibitor BAY 117082 alleviated RSL3-induced ferroptosis both in vitro and in vivo , indicating the critical role of this pathway

It is known that Down patients suffer from mild to moderate oxidative stress due to the overexpression of the Cu-Zn superoxide dismutase (SOD) gene that is also located on chromosome 21 [62]

We show that Glutathione S-transferase 4 (Gsta4) is highly expressed during adult OL differentiation and that Gsta4 loss impairs differentiation into myelinating OLs in vitro

Yet the cognitive enhancement effects triggered during exposure persist for weeks through sustained upregulation of hepatocyte growth factor (HGF) and its receptor c-Met in hippocampal tissue

S2) (Li et al