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A few small bubbles can be normal, but significant foam is a red flag that you may have been too aggressive

Along with the beneficial effect noted with fundoscopy assessment, all BPC 157 rats (both g- and ng-regimen, those that received medication at 20 min after L-NAME, and those that received medication at 48 h after L-NAME) commonly presented preserved plexiform and inner nuclear layer and retinal thickness (Figure 6, Figure 7)