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Curcumin Curcumin is the main natural polyphenol extracted from the rhizome of Curcuma longa L., which has been traditionally used in Asian countries as a medical herb for thousands of years (Kotha and Luthria, 2019)

NO modulates mitochondrial biogenesis also during myocytes differentiation by S-nitrosylation-mediated activation of the transcription factor CREB (cAMP response element-binding protein), which efficiently binds to the PGC-1a gene promoter region increasing its concentration and downstream signaling events [76]

Always keep the container tightly closed when not in use

3.1 A schematic diagram showing the enteral routes of drug administration (oral, sublingual and rectal) and their relative susceptibility to first-pass elimination, influencing the absorption and bioavailability of a drug

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