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Native Americans were chewing on the bark of the white willow for pain relief and fever reduction long before the barks salicin led to the invention (and, later, FDA approval) of aspirin

doi: 10.1146/annurev.immunol.15.1.351 191 LeiHWangGZhangJHanQ

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Given the pivotal role of the system Xc -GSH-GPX4 axis in ferroptosis defense, inhibiting GPX4 or SLC7A11 has emerged as a promising strategy to induce ferroptosis in PDAC