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Cell Metabolism , 31(3), 529544

Researchers should understand this status and its implications for safety and legality

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Potential Benefits & Side Effects Observations from preclinical and early research literature

Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease