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In aqueous solution, it tends to form block copolymer aggregates and have enhanced oxidation-responsiveness

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Confocal microscopy analysis of RBCs from chronic arsenic-exposed rats gave evidence of Fas aggregation and DISC assembly in the cell membrane that culminated in caspase-8 and caspase-3 activation

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Supplementation with NO donors (e.g., sodium nitroprusside) restores NO-cGMP-cGKI signaling in erythrocytes, inhibits PS externalization, and prolongs erythrocyte lifespan in CKD models ( 5.3 Antioxidants Antioxidants represent a critical class of eryptosis inhibitors, primarily targeting oxidative stressa central driver of accelerated eryptosis in chronic kidney disease (CKD)-related renal anemia