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Abdominal fat increases intra-abdominal pressure, forcing stomach contents upward against the lower esophageal sphincter

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Individuals with a personal history of acnewhether during adolescence or adulthoodmay theoretically be more susceptible, as their skin may already have a propensity towards follicular inflammation and altered sebaceous gland activity

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The gut produces these compounds in response to various signals, including the presence of beneficial bacteria, the integrity of the intestinal lining, and inflammatory status