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Demonstrating biological activity whether administered systemically, locally, orally, or intraperitoneally in pre-clinical models and and by the breadth of its cytoprotective, tissue repair, and angiogenic effects across virtually every organ system examined in the research literature

2014 follow-up study was retracted in 2025, which means the foundational evidence base has significant integrity concerns that should be weighed carefully

A synthetic cell-penetrating peptide engineered from a fragment of the FOXO4 protein, also known as Proxofim, FOXO4-DRI is studied as a senolytic that clears worn-out cells

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