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For example, mitophagy mediated MQC heavily depends on efficient lysosome degradation, whose dysregulation reversely suppresses mitochondrial function, so they all interplay by each other to form a vicious cycle, participating in the pathogenesis of neurodegenerative diseases

This does not necessarily exclude BDNF from mediating the improved memory of elderly subjects maintained on dietary restriction as peripheral BDNF levels were reported and neural BDNF levels remained unknown [182]

Alzheimers Dement 2018;14(2):121129