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Higher values for the DDE/DDT ratio are characteristic of a high prevalence of DDE in the environment and its constant bioaccumulation

Among these nanosytsems, polymer-based carriers, including polycaprolactone (PCL), polyethylene glycol (PEG), and chitosan, PLGA, offered an attractive biodegradable platform for encapsulating both synthetic drugs and bioactive natural compounds 29

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A phase I clinical trial of injecting NGF-expressing fibroblasts into the nucleus basalis of AD patients showed sustained NGF expression up to one year following injection and this was accompanied with cognitive improvement [49]