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We thank Mark Cleasby, PhD, from Liwen Bianji, Edanz Group China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript

Synthesis of creatine is regulated by the GATM (l-arginine:glycine amidinotransferase) and GAMT (guanidinoacetate-N-methyltransferase) enzymes (Schrama et al., 2022)

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However, the findings of this meta-analysis are limited by the small number of studies and MRS quality in some of the included studies

In another study investigating the relationship between oxidative stress and neuroinflammatory response in an LPS-induced depression model in mice and TXR treatment, it was revealed that TXR increased GSH and SOD levels and decreased MDA, TNF-, Interleukin 6 and interferon-gamma levels compared to negative control [101]