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Decrease in violent crime, DUI risk drunk driving Incredible how few DUI we have giving how every CVS, restaurant, bar you drive by is selling drugs (alcohol) People with APOE4 who drink alcohol are at even more risk as the alcohol adds more stress on top of stress and cells are now more likely to die Exercise is very important to reduce risk for APOE4 people Im not trying to just lose weight, Im trying to avoid having my brain atrophy when Im older Mouse study : Exercise causes your muscle cells to de-toxify kynurenine which is a byproduct of tryptophan metabolism (precursor to serotonin in the brain) Form kynurenine under stress, helps make T-cells Make too much kynurenine (dont get tryptophan) it can cross blood-brain barrier and create quinaloic acid , a neurotoxin, that actual kills cells in the brain, activates microglia/inflammation Also can cause depression by reducing amount of serotonin (exercise took the depression away) Exercises during the kynurenine into something else so it cant get in the brain Exercise is awesome of TONS of reasons, just do it

Thus, pharmacological inhibition of dipeptidyl peptidase 1 potentially reduces the contribution of aberrant NSP activity to the severity and/or progression of multiple inflammatory diseases

Most users experience more gradual improvement

N-acetyl cysteine reverses bio-behavioural changes induced by prenatal inflammation, adolescent methamphetamine exposure and combined challenges

Mol Cell 35:479489