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Muscle Weakness and Heaviness: When cells are insulin resistant, they cannot access the glucose needed for muscle contraction, leading to a reliance on lactic-acid-producing anaerobic metabolism

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Isolated from Aspergillus japonicus TPR-64 in 1978, 1 is a classic trans -epoxysuccinic acid ( t -ES)-based irreversible, potent and selective inhibitor against cysteine proteases such as papain, calpain and cysteine cathepsins 5,14,15 (Fig