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All deaths annually attributable to alcohol, illicit drug use, human immunodeficiency disease, homicides, suicides, and car accidents combined do not equal the number caused annually by cigarette smoking

Humans view, among other things, emotional investment, mutual vulnerability, shared moral agency, humor, continuity, and existential reciprocity as foundational to meaningful relationships (Bickmore & Picard, 2005

Brody AL, Mandelkern MA, Olmstead RE, Jou J, Tiongson E, Allen V et al (2007)