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S-BM cells exhibit increased glycolytic activity, resulting in elevated lactate production

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96,97 Moreover, the ME1 protein is hypophosphorylated at S336 and hyperacetylated at K337 by PGAM family member 5 and acetyl-CoA acetyltransferase, respectively, resulting in ME1 translocation from mitochondria to the cytosol, dimerization and activation, thus strongly promoting NADPH generation and tumorigenesis