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PMID 22787590

Starting with a small dose allows the body to adjust to the medication

We use methylcobalamin, the biologically active form of B12 most readily utilized by the body, more effective than the cyanocobalamin found in most over-the-counter supplements, which requires conversion before the body can use it

While the kidney is traditionally known as the primary site for 1,25(OH) 2 VD production, recent research reveals the presence of CYP27B1 in non-renal cells and tissues, suggesting localized formation of 1,25(OH) 2 VD and its tissue-specific paracrine role across various tissues [7]