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Chapman LE, Darling AL, Brown JE (2015) The association between the biguanide drug metformin and vitamin B 12 deficiency in diabetic patients: a systematic review

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This lipolytic effect appears to be mediated through activation of 3-adrenergic receptors on adipocytes, which are G-protein coupled receptors that, when activated, stimulate adenylyl cyclase to increase intracellular cAMP levels

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