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These substances include nicotine, carcinogens, acrolein, diethylene glycol, cadmium, benzene, and heavy metals

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Severe frostbite, when the deep tissue or extremity is frozen with a woody feeling and lifeless appearance, requires inpatient management and could be associated with life-threatening hypothermia

Second, although many cases were initially considered, the study had to exclude a significant number of patients to ensure data integrity and account for factors such as age, routine lung function tracking, influenza vaccination time, and smoking status

J Gastroenterol Hepatol 23 Suppl 1: S119-121, 2008