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Unlike high-dose GH administration, sermorelin is not known to cause significant fluid retention, carpal tunnel syndrome, or organomegaly in the doses used for deficiency treatment

This corresponds to about 1 to 3 million Americans age 65 and older with SCD and Alzheimer's disease, or 2 million as the middle estimate, corresponding to stage 2 in the new clinical staging criteria (see Table 3A)

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