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In addition, glutathione plays an important role in governing the liver's redox balance, thereby protecting liver cells from oxidative damage caused by the reactive oxygen species (ROS) produced during the detoxification process

Plant Cell 19 , 24702483 (2007)

[PMC free article: PMC4446235] [PubMed: 25754159] (Among 899 cases of drug induced liver injury enrolled in a prospective database between 2004 and 2012, HDS were implicated in 145 [16%], the single major herbal cause being green tea and only 2 cases had exposure to a kava containing product [Navarro et al Hepatology 2014])

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However, GSH depletion activates stress-activated protein kinases to promote necroptotic cell death 79