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FIGURE 15 Figure 16 represent the photomicrograph from the silver nitrate stained (Bielchowsky stain), and examination of the histological slides (Figure 16) that were obtained from rats in Group I (DMSO treated group) appears to be normal whereas slide (Figure 16) that was obtained from rats in Group II (traumatized non treated) shows the presence of axonal swelling (bulb) and axonal breaks
demonstrated thaterastin and RSL3 induced renal tubular cell death accompanied by high ACSL4 levels in vitro , while the ACSL4 inhibitor rosiglitazone improved the survival rate and alleviated kidney injury in diabetic nephropathy mice, and decreased lipid peroxidation products and iron content (Wang et al., 2020)
Despite these exciting results, some caveats for interpretation of this study should be mentioned
doi: 10.1124/mol.107.034884
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