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Notably, in a recent umbrella review of 14 meta-analyses, assessing pro/synbiotics on weight changes, most studies revealed a decrease in BMI and/or weight, favoring pro/synbiotics compared with placebo (26)

This energy exhaustion will further lead to the production of reactive oxygen species (ROS), apoptosis, and abnormal calcium homeostasis, which will promote epilepsy, thus forming a vicious circle (5)

In a mouse study, long-term consumption of a high-sugar diet altered gut microbiota composition, increasing harmful Firmicutes and decreasing beneficial Bacteroidetes, which is associated with gut barrier disruption (Alasmar et al., 2023)

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