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Ozempic: FDA-approved for the treatment of type 2 diabetes and, in higher doses under the name Wegovy, for chronic weight management

Moreover, compensatory activation of IGF-IR is involved in resistance to co-inhibition of EGFR and MEK in KRAS-mutated colorectal cancer cells [120]

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However, IGF-1 as prognostic factor was analyzed in a cohort of ALS patients with median follow-up of 67.6 months which is representative for the entire ALS registry Swabia 17