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In the 1980s, a pilot preclinical study on two rat and monkey PD models 16 and two independent clinical cases 17,18 showed that intracerebroventricular (i.c.v.) administration of dopamine improved motor symptoms, but also resulted in tachyphylaxia, possibly owing to dopamine oxidation despite the use of a preservative solution (sodium metabisulfite), precluding the therapeutic development of this concept

Final Thoughts Getting your B12 injection dosage right isnt about following some cookie-cutter protocol its about understanding your unique biology and optimizing based on real data instead of guessing

The American Journal of Clinical Nutrition, 89 (2), 693S6S

Evidence-based incorporation of serum sodium concentration into meld

doi: 10.1038/s41467-023-39759-w 112 YunJHFangAKhorshidiFHabibollahiPKutsenkoOEtezadiVet al