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The integration of MNs with deformable liposomes (e.g., ethosomes, transfersomes) enhances delivery efficacy, since the pliable vesicles can navigate via microchannels and release their contents directly into the dermis [275]

Varatharajalu et al., 2014)

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It says nothing about intestinal permeability, portal absorption, hepatic first-pass metabolism, or systemic distribution