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Furthermore, there is evidence that metformin could, via AMPK activation, improve HDL antioxidant and antiinflammatory activities in mice (Ma et al., 2017)

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Furthermore, bile acids have also been shown to regulate the interaction in the gut-brain axis (Gan et al., 2024a).Some studies have indicated an increasing trend in the abundance of Ruminococcus in the P.g -treated mouse group (Kato et al., 2018), and certain Ruminococcus species, such as Ruminococcus torques ( R.t ), possess direct vitamin D hydroxylation potential (Yamamoto and Jrgensen, 2019)

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