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In the context of severe intestinal lesions such as the crypt loss observed in inflammatory bowel disease (IBD), LGR5 + intestinal stem cells (ISCs) vigorously proliferate and differentiate to replenish the cellular pool essential for restoring the epithelial barrier, thus promoting epithelial regeneration post-injury 1,2

Adverse Reactions / Side Effects Nausea Diarrhea Decreased appetite Vomiting Constipation Dyspepsia (indigestion) Abdominal pain If side effects are severe or persistent, contact your healthcare provider

Exosomes mitigate POF by exerting anti-apoptotic activities, such as exosomal miR-21-5p inhibiting PTEN and caspase-3, hence decreasing GC apoptosis

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Can be taken directly or mixed into water or any beverage