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Ever since the Stride-PD trials of early adjunct treatment with entacapone in PD patients initiated on levodopa [129] there has been an unresolved debate on the potential benefit of LD/COMT-I combination in early PD

All forms of vitamin E (tocopherols, tocotrienols) are absorbed equally

The nutrient family Vitamin A includes preformed retinoids and provitamin A carotenoids

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Furthermore, additional experiments under forced desynchrony conditions are necessary to assess whether urolithin A can restore rhythmicity in adverse conditions