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You use the entire vial, nothing wasted, and then reconstitute a fresh vial for the next dose level

In one embodiment, administration of any formulation described herein at about body temperature reduces or inhibits vertigo associated with intratympanic administration of otic formulations

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Notably, normal rats exhibited a superior sagittal sinus pressure in a range from 24 to 27 mmHg, and a portal pressure of 35 mmHg similar to that of the inferior vena cava, though with at least 1 mmHg higher values in the portal vein