At the same time, it suppresses expression of C-C chemokine ligand 2 (CCL2/MCP-1) and CCL5 (RANTES), which are important chemoattractants for monocytes and macrophages, thereby disrupting the inflammatory microenvironment that supports lesion survival, angiogenesis, and fibrosis ( In vivo , intraperitoneal administration of luteolin in autologous EMs mouse models causes clear lesion regression, with significant volumetric reduction and structural simplification of ectopic implants
doi:10.1038/s41430-021-00875-9 Mansuri NM, Mann NK, Rizwan S, et al
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