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Since the regulation of Nrf2 activity is dependent on the ability of this protein to disengage from KEAP1 and translocate to the nucleus and there is evidence of cross talk between this antioxidant response pathway and others (e.g., adipogenic, ubiquitin, inflammatory) the development of small molecules that mimic Nrf2 activity and/or weaken its interaction with KEAP1 also represent a fertile area of pharmacologic exploration (Wakabayashi et al

P., Stylianopoulos, T., Martin, J

Nanog safeguards pluripotency and mediates germline development

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It raises decorin levels by 302%, a proteoglycan that organizes collagen into stable, functional structures