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These washout periods, which have been updated slightly since the 2022 List documents were published on 30 September to incorporate the latest scientific information, are highlighted in the revised version of the Summary of Major Modifications and Explanatory Note, and are based on the use of these medications according to the maximum manufacturers licensed doses

females of childbearing potential should discontinue semaglutide at least 2 months before a planned pregnancy due to the drugs long washout period

Similarly, brown adipose cells, already primed for thermogenesis, might respond to AOD9604 with a pronounced spike in energy expenditure

Standard clinical escalation protocol The Phase 2 trial published in the New England Journal of Medicine established the titration schedule that most researchers follow

Off-label use in this population should involve pediatric endocrinologists with expertise in weight management