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Muscle atrophy and sports medicine research&Wound healing and tissue engineering Indications: muscular dystrophy, AIDS related muscle consumption, muscle atrophy caused by long-term bed rest.Experimental Design:Animal model: Rats were subcutaneously injected with 0.1-0.3 mg/kg IGF-1 LR3, three times a week for 12 weeks, and the results showed a 15-20% increase in muscle strength.Cell experiment: In the myotube culture system, IGF 1 LR3 1mg can induce upregulation of myosin heavy chain (MyHC) expression and promote muscle fiber type transformation
Forrester SJ, Kikuchi DS, Hernandes MS et al (2018) Reactive oxygen species in metabolic and inflammatory signaling
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