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10.1073/pnas.1815150116 20 AyaA

Axonal degeneration, impaired axonal transport, and synaptic dysfunction in motor neuron disorder

Vitamin B12 is water-soluble, so excess is excreted naturally

Selenium supplementation also may exert a protective effect against mercury, cadmium, and other heavy metal toxicities

For instance, it is reported that during human ageing there is a shift towards global hypomethylation, resulting in the increased expression of pro-ageing genes, such as oncogenes and the genes that encode for pro-inflammatory cytokines.[19] Results from several studies indicate that diet and lifestyle drive the altered methylation patterns