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Furthermore, the 5xFAD mouse, which overexpresses human APP with three mutations along with human presenilin 1 (PS1) harboring two mutations, begins to show significant apathy-like behaviors from six months of age, as measured by nest-building, burrowing, and marble burying (Pugh et al., 2007

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Aging is considered the major risk factor for the insurgence and development of many neurodegenerative diseases, as also confirmed by studies describing the autophagy reduction in aging CNS cells [46,47,48]

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