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184 Overall, natural and synthetic SIRT1 activators rely on SIRT1s multi-dimensional roles in metabolism, inflammation, and oxidative stress regulation in MASLD, as shown in Table 1

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By supplementing with S-Acetyl-L-glutathione, we can replenish the levels of this essential antioxidant, helping to reduce oxidative stress and promote cellular function, thereby supporting the aging process

SFN is able to react with the thiol groups of Keap 1 and form thionacyl adducts promoting Nrf2 dissociation from Keap1 and subsequent activation of ARE driven gene expression and this may explain the increased GSH levels measured in control cells following SFN treatment