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A cross-sectional study of 700 community-living, physically disabled women over the age of 65 found that vitamin B 12 -deficient women were twice as likely to be severely depressed as non-deficient women (97)

SuLShenLClayburghDRNalleSCSullivanEAMeddingsJBet alTargeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis

While these represent uncontrolled single-person reports rather than systematic evidence, they align with the preclinical research findings

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