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This can lead to copper sequestration in misfolded fibrils along with copper deficiency in the mitochondria, causing impaired energy production ( At least one histidine residue is present in the majority of amyloidogenic proteins, and these histidine residues interact with copper in important ways, influencing their conformational shape

The copper ion sits in a square-planar pyramid configuration, creating an extraordinarily high binding affinity approximately 10 million times higher than other tripeptides

Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma

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