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Psychiatry, 13 , 611616

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Harpavat S, Cepko CL

In fact, a specific cellular signaling pathway has been described in mice, including the activation of protease-activated receptor 2 and downstream enzymes phospholipase C and protein kinases A and C by mast cell triptase, and resultant sensitization of TRPV1, TRPV4, and TRPA1 (Chen et al., 2012) observed in vitro that paclitaxel administration induced oxidative stress byproducts which ultimately activate TRPA1 and TRPV4

A washout interval of 2 to 4 weeks was maintained between each arm of the crossover to minimize potential carryover effects