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It appeared to increase density and thickness of photodamaged skin compared to control compound likewise evaluated

doi:10.1038/nature04056

Real-world research example: Researchers using a formulation like PureRawz DSIP + Melatonin often start with 12 sprays (50100 mcg DSIP) 30 minutes before bed

These numbing agents may provide temporary relief but often lead to contact dermatitis, adding another layer of irritation to an already painful situation